Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168317 | 0.92 | F2RL3 (0.44) | ALOX5APPTGS1F2RL3KMT2AEDNRB | |
| SCHEMBL2808138 | 0.85 | SERPINE1 (0.47) | KMT2AEDNRBEDNRAPLA2G2APPARG | |
| SCHEMBL6851257 | 0.83 | PLA2G2A (0.53) | KMT2AEDNRBEDNRAPLA2G2APPARG | |
| SCHEMBL2810080 | 0.83 | EDNRB (0.46) | ALOX5APPTGS1F2RL3KMT2AMEN1 | |
| SCHEMBL2808197 | 0.83 | PLA2G2A (0.46) | F2RL3EDNRBEDNRAPLA2G2APPARG | |
| SCHEMBL6859336 | 0.78 | PPARG (0.54) | KMT2AMEN1EDNRBEDNRAPLA2G2A | |
| SCHEMBL13168236 | 0.77 | SERPINE1 (0.46) | KMT2APLA2G2APPARG | |
| SCHEMBL17600664 | 0.77 | F2RL3 (0.59) | F2RL3KMT2APLA2G2APPARG | |
| SCHEMBL6858332 | 0.76 | PPARG (0.50) | KMT2AEDNRBEDNRAPLA2G2APPARG | |
| SCHEMBL2805777 | 0.76 | SERPINE1 (0.42) | KMT2AMEN1EDNRBEDNRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
| EP-2081894-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SmithKline Beecham Corporation (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008028118-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SMITHKLINE BEECHAM CORPORAITON (US) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240642-A1 | 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators | PPARD, PPARA, PPARG | ALOX5AP 440/4885PTGS1 508/4885F2RL3 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.