Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.52 |
| ▸ | JAK1 | P23458 | 9/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345642 | 0.86 | JAK3 (0.70) | JAK3JAK1JAK2BTK | |
| SCHEMBL28345574 | 0.83 | JAK1 (0.70) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL16765519 | 0.80 | JAK3 (0.78) | JAK3JAK1BTK | |
| SCHEMBL17350335 | 0.80 | JAK3 (0.72) | JAK3JAK1JAK2TYK2DOT1L | |
| SCHEMBL17350131 | 0.79 | JAK2 (0.76) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL30976754 | 0.79 | JAK3 (0.47) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2113254 | 0.78 | HPGDS (0.58) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL24121894 | 0.77 | JAK3 (0.58) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL13961118 | 0.77 | JAK3 (0.58) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12613724 | 0.76 | JAK3 (0.48) | JAK3JAK1JAK2TYK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-A | Azaindole derivatives, preparation method and applications thereof in medicine | 上海润诺生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |