Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.47 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL27448289 | 0.91 | MEN1 (0.47) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL15193 | 0.87 | — | — | |
| SCHEMBL9359592 | 0.87 | MEN1 (0.67) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL29371456 | 0.87 | — | — | |
| SCHEMBL4365400 | 0.85 | MEN1 (0.58) | MEN1NPC1RAB9AKMT2AATM | |
| Cyclohexane SCHEMBL9193794 | 0.85 | RAB9A (0.58) | MEN1NPC1RAB9AKMT2AATM | |
| Phosphine SCHEMBL3755463 | 0.85 | — | — | |
| Iodide SCHEMBL1274592 | 0.85 | — | — | |
| SCHEMBL11734134 | 0.85 | — | — | |
| SCHEMBL17201491 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745300-B | Method of consolidating solid materials during subterranean treatment operations | 韦特福特科技控股有限责任公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-104073179-B | Adhesive tape for electrochemical device | 日东电工（上海松江）有限公司 | 2019-05-07 | — | — | CN | disclosed |
| CN-106103621-B | Adherence composition, sticker and adhesive sheet | 琳得科株式会社 | 2019-01-11 | — | — | CN | disclosed |
| CN-105517479-B | Bond cleaner | 尼托母斯股份有限公司 | 2018-05-15 | — | — | CN | disclosed |
| CN-107249420-A | Bond cleaner | 尼托母斯股份有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-102918701-B | Polyether functionalized redox shuttle additives for lithium ion batteries | U芝加哥阿尔贡股份有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-106170527-A | For producing the method and system in high flow conductivity crack | 路博润油田解决方案公司 | 2016-11-30 | — | — | CN | disclosed |
| CN-106103621-A | Adherence composition, sticker and adhesive sheet | 琳得科株式会社 | 2016-11-09 | — | — | CN | disclosed |