Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944813 | 0.83 | FGFR1 (0.35) | FGFR1KDRMAPK1AXLCDK8 | |
| SCHEMBL12986192 | 0.79 | FGFR1 (0.36) | CYP3A4CYP1A2FGFR1KDRMAPK1 | |
| SCHEMBL1093257 | 0.78 | BRD4 (0.43) | CYP1A2FGFR1KDRMAPK1AXL | |
| SCHEMBL1763317 | 0.77 | GPR84 (0.38) | FGFR1KDRAXLRAB9ASMN1; SMN2 | |
| SCHEMBL13021084 | 0.75 | CYP1A2 (0.40) | CYP2D6CYP3A4CYP2C9CYP2C19CYP19A1 | |
| SCHEMBL5067972 | 0.74 | AXL (0.38) | FGFR1KDRCDK1CDK2MAPK1 | |
| SCHEMBL21462266 | 0.74 | TLR7 (0.42) | CYP2D6CYP3A4TTBK1TTBK2 | |
| SCHEMBL1444090 | 0.71 | MEN1 (0.46) | CDK2RAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL16266763 | 0.69 | MERTK (0.37) | FGFR1KDRAXLCDC7CHEK1 | |
| SCHEMBL20508764 | 0.69 | DYRK1A (0.38) | FGFR1KDRPIM1DYRK1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906631-A | Compounds and methods for kinase modulation, and indications therefor | 普莱希科公司 | 2016-08-31 | — | — | CN | disclosed |