Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL18939741 | 0.98 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082794 | 0.96 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082535 | 0.96 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082875 | 0.96 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082942 | 0.96 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL3771501 | 0.91 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28494369 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28063324 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL585339 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL409860 | 0.84 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814092-B | Composition for hydrophilic cured product | 三井化学株式会社 | 2018-09-21 | — | — | CN | disclosed |
| CN-107430213-A | Hydrophilic optical feature monofilm and its layered product | 三井化学株式会社 | 2017-12-01 | — | — | CN | disclosed |
| CN-105814092-A | Composition for hydrophilic cured product | 三井化学株式会社 | 2016-07-27 | — | — | CN | disclosed |