Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.58 |
| ▸ | TET3 | O43151 | 2/20 | 0.58 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL28083031 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082942 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082875 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082794 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28082535 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28494369 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL3771501 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL28063324 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL585339 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL409860 | 0.85 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119799159-A | Bio-based UV curing release agent, preparation method thereof and release film | 江苏斯迪克新材料科技股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-110007562-A | Photopolymerizable unsaturated-resin and photosensitive resin composition containing the photopolymerizable unsaturated-resin | 罗门哈斯电子材料韩国有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-103890659-A | Photopolymerizable unsaturated resin, photosensitive resin composition containing the same, and light-shielding spacer and liquid crystal display device prepared therefrom | ROHM & HAAS ELECT MAT | 2014-06-25 | — | — | CN | claimed |
| CN-119799159-A | Bio-based UV curing release agent, preparation method thereof and release film | 江苏斯迪克新材料科技股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-119799159-A | Bio-based UV curing release agent, preparation method thereof and release film | 江苏斯迪克新材料科技股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-111978444-B | Organic polyacid-based photocuring resin and preparation method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2022-03-08 | — | — | CN | disclosed |
| CN-111978444-A | Organic polyacid-based photocuring resin and preparation method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2020-11-24 | — | — | CN | disclosed |
| WO-2020023620-A1 | METHODS AND COMPOSITIONS OF CHEMICALLY MODIFIED PHAGE LIBRARIES | TRUSTEES OF BOSTON COLLEGE (US) | 2020-01-30 | — | — | WO | disclosed |
| CN-110007562-A | Photopolymerizable unsaturated-resin and photosensitive resin composition containing the photopolymerizable unsaturated-resin | 罗门哈斯电子材料韩国有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105814092-B | Composition for hydrophilic cured product | 三井化学株式会社 | 2018-09-21 | — | — | CN | disclosed |
| CN-107430213-A | Hydrophilic optical feature monofilm and its layered product | 三井化学株式会社 | 2017-12-01 | — | — | CN | disclosed |
| US-20170166575-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING SAID COMPOUND | ADEKA CORPORATION (JP) | 2017-06-15 | — | — | US | disclosed |
| CN-105814092-A | Composition for hydrophilic cured product | 三井化学株式会社 | 2016-07-27 | — | — | CN | disclosed |
| CN-103890659-A | Photopolymerizable unsaturated resin, photosensitive resin composition containing the same, and light-shielding spacer and liquid crystal display device prepared therefrom | ROHM & HAAS ELECT MAT | 2014-06-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166575-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING SAID COMPOUND | RB1, PRMT9, KDM2B | SMN1; SMN2 1051/4885TET2 137/4885TET3 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.