Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2,6-Diaminopurine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.79 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.79 |
| ▸ | CDK1 | P06493 | 14/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 14/20 | 0.56 |
| ▸ | CDK2 | P24941 | 13/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.56 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.54 |
| ▸ | MGMT | P16455 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Diaminopurine SCHEMBL29143272 | 0.89 | PDPK1 (0.92) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL24053 | 0.89 | PDPK1 (1.00) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL28206545 | 0.87 | PDPK1 (0.96) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL8757979 | 0.87 | PDPK1 (0.96) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL27891733 | 0.87 | PDPK1 (0.96) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL1033682 | 0.84 | PDPK1 (0.82) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL13857840 | 0.83 | PDPK1 (0.79) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL3238169 | 0.83 | PDPK1 (0.79) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL30680639 | 0.83 | PDPK1 (0.79) | PDPK1GDACDK1CCNB1CDK2 | |
| 2,6-Diaminopurine SCHEMBL4535059 | 0.83 | PDPK1 (0.79) | PDPK1GDACDK1CCNB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107459544-B | Substituted nucleosides, nucleotides and analogs thereof | 詹森生物制药有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-102459597-B | Treatment of dystrophin family-related diseases by inhibition of natural antisense transcript to DMD family | 库尔纳公司 | 2020-06-30 | — | — | CN | disclosed |
| CN-110917205-A | Substituted nucleosides, nucleotides and analogs thereof | 詹森生物制药有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-110177877-A | Antisense oligonucleotides | 新加坡科技研究局 | 2019-08-27 | — | — | CN | disclosed |
| CN-107459544-A | Substituted nucleosides, nucleotides and the like | 艾丽奥斯生物制药有限公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-104114568-B | Substituted nucleosides, nucleotides and analogs thereof | 艾丽奥斯生物制药有限公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-106794256-A | Protein/oligonucleotide core-shell nanoparticle therapeutics | 西北大学 | 2017-05-31 | — | — | CN | disclosed |
| CN-103301475-B | Method that pharmaceutical composition and expression vector and regulator gene are expressed and the application of nucleic acid molecules | 斯克里普斯研究所 | 2016-08-03 | — | — | CN | disclosed |