Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Moxalactam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.69 |
| ▸ | PGR | P06401 | 3/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 4/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 4/20 | 0.55 |
| ▸ | SLC22A11 | Q9NSA0 | 4/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftriaxone SCHEMBL3389557 | 0.96 | NR1I2 (0.64) | NR1I2PGRPTGS1TDP1HSD17B10 | |
| Moxalactam SCHEMBL6521966 | 0.96 | NR1I2 (0.64) | NR1I2PGRPTGS1TDP1HSD17B10 | |
| Moxalactam SCHEMBL13723425 | 0.94 | PTGS1 (0.64) | NR1I2PGRPTGS1TDP1HSD17B10 | |
| Ceftazidime SCHEMBL715368 | 0.89 | NR1I2 (0.58) | NR1I2PGRPTGS1TDP1HSD17B10 | |
| Moxalactam SCHEMBL22205083 | 0.87 | NR1I2 (0.52) | NR1I2PGRPTGS1TDP1HSD17B10 | |
| Cefmenoxime SCHEMBL152861 | 0.83 | NR1I2 (1.00) | NR1I2PGRTDP1HSD17B10SLC22A6 | |
| Cefmenoxime SCHEMBL1813696 | 0.83 | NR1I2 (1.00) | NR1I2PGRTDP1HSD17B10SLC22A6 | |
| Cefmenoxime SCHEMBL9659869 | 0.83 | NR1I2 (1.00) | NR1I2PGRTDP1HSD17B10SLC22A6 | |
| Cefmenoxime SCHEMBL16072811 | 0.83 | NR1I2 (1.00) | NR1I2PGRTDP1HSD17B10SLC22A6 | |
| Cefmenoxime SCHEMBL10633730 | 0.83 | NR1I2 (1.00) | NR1I2PGRTDP1HSD17B10SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |