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Prednylidene

Prednylidene

SCHEMBL28086556

C=C1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.CCC(=O)[C@@]1(C)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Prednylidene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 12/20 0.79
▸ PGR P06401 4/20 0.79
▸ HIF1A Q16665 4/20 0.79
▸ LMNA P02545 2/20 0.79
▸ NR1I2 O75469 1/20 0.79
▸ CNR1 P21554 1/20 0.79
▸ CYP3A4 P08684 4/20 0.58
▸ HSD17B10 Q99714 3/20 0.58
▸ ABCB11 O95342 2/20 0.58
▸ NR3C2 P08235 2/20 0.58
▸ AR P10275 2/20 0.58
▸ TNF P01375 1/20 0.58
▸ IL6 P05231 1/20 0.58
▸ SERPINA6 P08185 1/20 0.58
▸ GLUL P15104 1/20 0.58
▸ ADAM17 P78536 1/20 0.58
▸ GPBAR1 Q8TDU6 1/20 0.58
▸ CYP2C19 P33261 1/20 0.58
▸ ABCC3 O15438 1/20 0.54
▸ ABCC4 O15439 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prednylidene SCHEMBL6257149 0.91 NR3C1 (0.66) NR3C1PGRHIF1ALMNANR1I2
Prednylidene SCHEMBL1650347 0.90 NR3C1 (0.70) NR3C1PGRHIF1ALMNANR1I2
Prednylidene SCHEMBL19327135 0.90 NR3C1 (0.70) NR3C1PGRHIF1ALMNANR1I2
Prednylidene SCHEMBL7568 0.90 NR3C1 (0.70) NR3C1PGRHIF1ALMNANR1I2
Prednylidene SCHEMBL3291132 0.90 NR3C1 (0.70) NR3C1PGRHIF1ALMNANR1I2
Rimexolone SCHEMBL3062722 0.89 NR3C1 (1.00) NR3C1PGRHIF1ALMNANR1I2
Rimexolone SCHEMBL13693339 0.89 NR3C1 (1.00) NR3C1PGRHIF1ALMNANR1I2
Rimexolone SCHEMBL29030108 0.89 NR3C1 (1.00) NR3C1PGRHIF1ALMNANR1I2
Rimexolone SCHEMBL445300 0.89 NR3C1 (1.00) NR3C1PGRHIF1ALMNANR1I2
Rimexolone SCHEMBL29030109 0.89 NR3C1 (1.00) NR3C1PGRHIF1ALMNANR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 — — CN disclosed
CN-103492389-B Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases 原真股份有限公司 2016-09-14 — — CN disclosed