Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL29239528 | 0.78 | ALDH1A1 (0.45) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28144363 | 0.77 | ALDH1A1 (0.55) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28318728 | 0.77 | ALDH1A1 (0.55) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28140139 | 0.77 | ALDH1A1 (0.55) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28213101 | 0.76 | ALDH1A1 (0.53) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28096623 | 0.73 | ALDH1A1 (0.77) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28267407 | 0.73 | ALDH1A1 (0.77) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL5875146 | 0.73 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL18804794 | 0.73 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28273361 | 0.73 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101904-A | A kind of method for preparing quinoquinazolone derivative | 苏州大学张家港工业技术研究院 | 2018-06-01 | — | — | CN | claimed |
| CN-110372611-A | A kind of method of the polysubstituted dihydroquinazoline ketone of selectivity synthesis or quinazolinone | 常熟理工学院 | 2019-10-25 | — | — | CN | disclosed |
| CN-108727371-A | Bis- (substituted-phenyl) quinazolinones of 2,8- and its preparation method and application | 浙江工业大学 | 2018-11-02 | — | — | CN | disclosed |
| CN-108623584-A | Bis- (aryl ethane base) quinazolinones of 2,8- and its preparation method and application | 浙江工业大学 | 2018-10-09 | — | — | CN | disclosed |
| CN-108558872-A | A kind of 8- substituted-phenyls-quinazolinones and its preparation method and application | 浙江工业大学 | 2018-09-21 | — | — | CN | disclosed |
| CN-108503595-A | A method of preparing quianzolinones | 中国科学院大连化学物理研究所 | 2018-09-07 | — | — | CN | disclosed |
| CN-108484574-A | The preparation and application of tetrahydro isoquinoline derivative | 广东医科大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-108445033-A | A kind of assay method of the alkaloid optical purity of 4- (3H) quianzolinones | 温州大学 | 2018-08-24 | — | — | CN | disclosed |
| CN-107994062-A | Composition for forming light-emitting layer and method for manufacturing organic electroluminescent device | 三菱化学株式会社 | 2018-05-04 | — | — | CN | disclosed |
| CN-107936013-A | A kind of D π A π D type quinazolinone third order non-linear optical materials and its preparation method and application | 浙江工业大学 | 2018-04-20 | — | — | CN | disclosed |
| CN-107614510-A | Iridium complex compound, organic electroluminescent element containing iridium complex compound, display device, and lighting device | 三菱化学株式会社 | 2018-01-19 | — | — | CN | disclosed |
| CN-104024251-B | Benzenesulfonamide compounds and their use as therapeutic agents | 克赛农制药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-105017259-B | Quinazol derivative containing trifluoromethyl and its preparation method and application | 浙江大学 | 2017-07-21 | — | — | CN | disclosed |
| CN-106496146-A | Catalytic regulation synthesis method of sulfonic acid ionic liquid of dihydro quinazolinone and quinazolinone derivative | 江西师范大学 | 2017-03-15 | — | — | CN | disclosed |
| CN-104761558-B | A kind of one pot process quinazolinone the method for indazole derivative | 温州大学 | 2016-09-21 | — | — | CN | disclosed |