Pyrazine

Pyrazine

SCHEMBL28089293

C=CCc1cnccn1.c1cnccn1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.35
HSP90AA1 P07900 1/20 0.34
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
VNN1 O95497 1/20 0.31
KDM4E B2RXH2 2/20 0.31
DAO P14920 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4D Q08499 1/20 0.30
NAPRT Q6XQN6 1/20 0.30
HCAR2 Q8TDS4 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL253297 0.98
SCHEMBL1778280 0.77 HSP90AA1 (0.33) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27671906 0.77 NAPRT (0.45) CYP1A2CYP3A4CYP2C9CYP2C19VNN1
SCHEMBL27650067 0.76
SCHEMBL30704808 0.76
SCHEMBL7374771 0.76
SCHEMBL1920222 0.76
Water SCHEMBL27651496 0.75 NAPRT (0.44) CYP1A2CYP3A4CYP2C9CYP2C19VNN1
SCHEMBL11788505 0.74 HSP90AA1 (0.34) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL980114 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109965339-A Tobacco processing 英美烟草(投资)有限公司 2019-07-05 CN disclosed
CN-105848502-B tobacco processing method 英美烟草(投资)有限公司 2019-04-16 CN disclosed
CN-105848502-A Tobacco treatment 英美烟草(投资)有限公司 2016-08-10 CN disclosed