SCHEMBL28089476

SCHEMBL28089476

CC(Br)OC(=O)c1cccnc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.62
MAPT P10636 2/20 0.61
KMT2A Q03164 7/20 0.53
LMNA P02545 4/20 0.52
L3MBTL1 Q9Y468 1/20 0.51
APP P05067 1/20 0.50
GAA P10253 1/20 0.50
HCAR3 P49019 1/20 0.50
HCAR2 Q8TDS4 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
TSHR P16473 1/20 0.49
CYP2C19 P33261 1/20 0.49
THRB P10828 1/20 0.49
ATM Q13315 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
F7 P08709 1/20 0.49
F3 P13726 1/20 0.49
SARM1 Q6SZW1 1/20 0.49
SIRT2 Q8IXJ6 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30827513 0.86 ALDH1A1 (0.78) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL1628833 0.86 ALDH1A1 (0.78) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL25391376 0.86 ALDH1A1 (0.61) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL29458655 0.85 ALDH1A1 (0.76) ALDH1A1MAPTKMT2ALMNAL3MBTL1
Hydrochloric Acid SCHEMBL8066446 0.85 ALDH1A1 (0.76) ALDH1A1MAPTKMT2ALMNAL3MBTL1
Ammonia Solution, Strong SCHEMBL27461059 0.85 ALDH1A1 (0.76) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL3027982 0.83 ALDH1A1 (0.62) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL847660 0.83 ALDH1A1 (0.62) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL13471433 0.83 ALDH1A1 (0.62) ALDH1A1MAPTKMT2ALMNAL3MBTL1
SCHEMBL3026613 0.83 ALDH1A1 (0.62) ALDH1A1MAPTKMT2ALMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107224436-B twin drug type HMG-CoA reductase inhibitor and synthesis method thereof 上海应用技术大学 2020-01-31 CN disclosed
CN-105899509-B Isopropyl triazolopyridine compounds 伊莱利利公司 2018-01-02 CN disclosed
CN-104193725-B Organic compound 诺华股份有限公司 2016-11-16 CN disclosed
CN-106029660-A P2X 3 and/or P2X 2/3 compounds and methods 阿萨纳生物科技有限责任公司 2016-10-12 CN disclosed
CN-105873929-A Phenyl-triazolo-pyridine compounds 伊莱利利公司 2016-08-17 CN disclosed