Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1446179 | 0.84 | HDAC6 (0.38) | HDAC6CTSKHDAC1HDAC2CA14 | |
| SCHEMBL18545396 | 0.81 | HDAC6 (0.37) | HDAC6HDAC1HDAC2 | |
| SCHEMBL30929705 | 0.81 | HDAC6 (0.41) | HDAC6CTSKHDAC1HDAC2HDAC3 | |
| SCHEMBL20326556 | 0.81 | HDAC6 (0.37) | HDAC6CTSKHDAC1HDAC2 | |
| SCHEMBL5990035 | 0.81 | HDAC6 (0.37) | HDAC6HDAC1HDAC2 | |
| SCHEMBL15155610 | 0.81 | HDAC6 (0.37) | HDAC6HDAC1HDAC2 | |
| SCHEMBL31478149 | 0.80 | HDAC6 (0.36) | HDAC6HDAC1HDAC2 | |
| SCHEMBL16351746 | 0.80 | HDAC6 (0.36) | HDAC6HDAC1HDAC2 | |
| SCHEMBL499275 | 0.80 | HDAC6 (0.38) | HDAC6CTSKHDAC1HDAC2CA14 | |
| SCHEMBL27828868 | 0.79 | HDAC6 (0.41) | HDAC6CTSKHDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-105764896-A | Inhibitors of Bruton's tyrosine kinase | 药品循环有限责任公司 | 2016-07-13 | — | — | CN | disclosed |