Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.49 |
| ▸ | JAK2 | O60674 | 10/20 | 0.49 |
| ▸ | JAK1 | P23458 | 9/20 | 0.49 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120005 | 0.84 | SYK (0.46) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL24144842 | 0.83 | JAK3 (0.44) | JAK3JAK2JAK1SYKAXL | |
| SCHEMBL30676600 | 0.81 | AXL (0.63) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL9887961 | 0.81 | AURKA (0.46) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL1427263 | 0.81 | AXL (0.63) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL1516568 | 0.81 | DYRK1A (0.48) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL4828101 | 0.81 | AURKA (0.54) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL28046056 | 0.81 | BRAF (0.53) | JAK3JAK2SYKCYP2C9AXL | |
| SCHEMBL28696802 | 0.79 | AXL (0.47) | JAK3JAK2SYKAXLPLK4 | |
| SCHEMBL4831062 | 0.78 | DYRK1A (0.48) | JAK3JAK2SYKAXLPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777756-A | Heteroaryl compound and application thereof in medicines | 广东东阳光药业有限公司 | 2016-07-20 | — | — | CN | disclosed |