Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | CLK2 | P49760 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10131672 | 0.91 | CSNK2A1 (0.49) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL28046056 | 0.90 | BRAF (0.53) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL8167329 | 0.89 | AURKA (0.50) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL1516568 | 0.87 | DYRK1A (0.48) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL15882691 | 0.87 | DYRK1A (0.48) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL28512135 | 0.87 | DYRK1A (0.48) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL4831062 | 0.87 | DYRK1A (0.48) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL4831069 | 0.85 | DYRK1A (0.53) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL1516742 | 0.84 | CDK2 (0.46) | AURKAJAK2PRKD3MAP4K4FGFR1 | |
| SCHEMBL7520159 | 0.84 | AURKA (0.46) | AURKAJAK2PRKD3MAP4K4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119241535-A | Pyrrolopyridinyl heterocyclic compound, preparation method and application thereof, derivative of pyrrolopyridinyl heterocyclic compound, application of derivative, pharmaceutical composition and application of derivative | 济宁医学院附属医院 | 2025-01-03 | — | — | CN | claimed |
| CN-108997340-B | Synthetic method of 5-bromo-7-azaindole | 山东轩德医药科技有限公司 | 2020-03-20 | — | — | CN | claimed |
| US-12486264-B2 | Bicyclic HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-02 | — | — | US | disclosed |
| US-12421226-B2 | Heteroaryl compounds as necrosis inhibitors, composition and method using the same | ACCRO BIOSCIENCE (HK) LIMITED (HK) | 2025-09-23 | — | — | US | disclosed |
| US-20250243181-A2 | NOVEL INDAZOLE DERIVATIVE AND USE THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2025-07-31 | — | — | US | disclosed |
| CN-120004785-A | Compounds and compositions for the treatment of diseases associated with STING activity | 诺华制药股份有限公司 | 2025-05-16 | — | — | CN | disclosed |
| EP-3947373-B1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-14 | — | — | EP | disclosed |
| CN-119241535-A | Pyrrolopyridinyl heterocyclic compound, preparation method and application thereof, derivative of pyrrolopyridinyl heterocyclic compound, application of derivative, pharmaceutical composition and application of derivative | 济宁医学院附属医院 | 2025-01-03 | — | — | CN | disclosed |
| CN-112823036-B | Compounds and compositions for the treatment of diseases associated with STING activity | 艾福姆德尤股份有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114867718-B | Indazole derivatives and use thereof | 韩国化学研究院 | 2024-10-01 | — | — | CN | disclosed |
| CN-118488947-A | Condensed ring substituted six-membered heterocyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2024-08-13 | — | — | CN | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| WO-2010020308-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421226-B2 | Heteroaryl compounds as necrosis inhibitors, composition and method using the same | TNF, LITAF, PNLIP | AURKA 4005/4885JAK2 1682/4885PRKD3 2384/4885 |
| US-12486264-B2 | Bicyclic HPK1 inhibitors | PCK1, PGK1, PDXK | AURKA 972/4885JAK2 3717/4885PRKD3 163/4885 |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | AURKA 884/4885JAK2 16/4885PRKD3 143/4885 |
| US-20250243181-A2 | NOVEL INDAZOLE DERIVATIVE AND USE THEREOF | TRIB2, YAP1, IDO2 | AURKA 1305/4885JAK2 2764/4885PRKD3 263/4885 |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | AURKA 384/4885JAK2 206/4885PRKD3 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.