Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11970184 | 0.81 | HCRTR1 (0.49) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL5023941 | 0.78 | MAPT (0.57) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL29586276 | 0.76 | MAPT (0.51) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL1913689 | 0.76 | MAPT (0.51) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL11955040 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL12352516 | 0.73 | MAPT (0.47) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL5018918 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL18906764 | 0.73 | MAPT (0.52) | MAPTALDH1A1KDM4EHPGDTHRB | |
| SCHEMBL6273166 | 0.73 | MAPT (0.46) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL17448256 | 0.72 | AHR (0.52) | MAPTALDH1A1KDM4EHPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661005-A | Functionalized and substituted indoles as anticancer agents | 诺沃根公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-105916841-A | Functionalised and substituted indoles as anti-cancer agents | 诺沃根公司 | 2016-08-31 | — | — | CN | disclosed |