Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094527 | 1.00 | CA1 (0.43) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL28129506 | 0.81 | CA1 (0.47) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL3448835 | 0.79 | CA2 (0.51) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL9288190 | 0.77 | CA1 (0.38) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL19211643 | 0.76 | CA2 (0.49) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL28094519 | 0.75 | CA2 (0.41) | CA1CA2CA9CA12CA14 | |
| SCHEMBL2852456 | 0.74 | CA1 (0.53) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL785066 | 0.74 | CA2 (0.46) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL28094137 | 0.73 | CA1 (0.49) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL17010332 | 0.72 | CA1 (0.35) | CA1CA2CA9MAPK1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829305-B | NRF2 regulator | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-105829305-A | NRF2 REGULATORS | 葛兰素史密斯克莱知识产权发展有限公司 | 2016-08-03 | — | — | CN | disclosed |