Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809526 | 0.89 | TSHR (0.40) | TSHRLMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL2809519 | 0.86 | HTR6 (0.45) | TSHRL3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL2811683 | 0.85 | PTGIR (0.40) | TSHRLMNAHRH3KDM4EHTR6 | |
| SCHEMBL2812073 | 0.83 | DNMT3A (0.43) | TSHRLMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL2809530 | 0.83 | MAPT (0.44) | L3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL2810409 | 0.82 | SRC (0.43) | TSHRLMNATP53KMT2AMEN1 | |
| SCHEMBL2810429 | 0.82 | KDM4E (0.44) | TSHRKDM4EHTR6 | |
| SCHEMBL2815921 | 0.81 | TSHR (0.42) | TSHRLMNATP53KMT2AMEN1 | |
| SCHEMBL2813977 | 0.79 | HRH3 (0.44) | HRH3KMT2AMEN1KDM4E | |
| SCHEMBL2809765 | 0.77 | POLB (0.49) | LMNAKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | TSHR 3555/4885LMNA 2815/4885L3MBTL1 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.