Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094569 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTRECQLNR1H2 | |
| SCHEMBL16824867 | 0.89 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTRECQLNR1H2 | |
| SCHEMBL18186263 | 0.89 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTRECQLNR1H2 | |
| SCHEMBL18186426 | 0.89 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTRECQLGAA | |
| SCHEMBL16824823 | 0.89 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTRECQLGAA | |
| SCHEMBL1814622 | 0.83 | ALDH1A1 (0.65) | ALDH1A1LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL30310805 | 0.83 | ALDH1A1 (0.65) | ALDH1A1LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL28094427 | 0.82 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTRECQLNR1H2 | |
| SCHEMBL18186308 | 0.81 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTRECQLNR1H2 | |
| SCHEMBL16824986 | 0.81 | ALDH1A1 (0.58) | ALDH1A1LMNAMAPTRECQLNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829315-B | Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors | 阿尔麦克探索有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-105829315-A | Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors | 阿尔麦克探索有限公司 | 2016-08-03 | — | — | CN | disclosed |