Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Phenylpropanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylpropanol SCHEMBL539164 | 0.97 | LMNA (1.00) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL27878996 | 0.97 | LMNA (1.00) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL698860 | 0.97 | LMNA (1.00) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL56673 | 0.97 | LMNA (1.00) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL27691663 | 0.97 | LMNA (1.00) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL28094107 | 0.95 | LMNA (0.86) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL19667852 | 0.95 | LMNA (0.95) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL9994261 | 0.95 | LMNA (0.95) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL11694956 | 0.95 | LMNA (0.95) | LMNAKDM4EL3MBTL1AOC3RIPK1 | |
| Phenylpropanol SCHEMBL27479853 | 0.95 | LMNA (0.95) | LMNAKDM4EL3MBTL1AOC3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106362641-B | A kind of dendritic interphase demulsifier and preparation method thereof | 威海晨源分子新材料有限公司 | 2018-12-04 | — | — | CN | claimed |
| CN-106362641-A | Dendritic polyamide-amine demulsifier and preparation method thereof | 威海晨源分子新材料有限公司 | 2017-02-01 | — | — | CN | claimed |
| CN-104860808-B | Two fluorine monomers containing tetraphenyl ethylene group and be used for preparing poly aryl ether ketone polymer | 吉林大学 | 2016-09-07 | — | — | CN | claimed |
| CN-106362641-B | A kind of dendritic interphase demulsifier and preparation method thereof | 威海晨源分子新材料有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-104230770-B | The application of styryl sulfone compound, its preparation method as well as neuroprotective agent | 华夏生生药业(北京)有限公司 | 2017-11-21 | — | — | CN | disclosed |
| CN-106362641-A | Dendritic polyamide-amine demulsifier and preparation method thereof | 威海晨源分子新材料有限公司 | 2017-02-01 | — | — | CN | disclosed |