Pyridine

Pyridine

SCHEMBL28096803

c1ccncc1.c1cnccn1.c1csc(-c2cccs2)c1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.59
CYP2C9 P11712 2/20 0.59
CYP2E1 P05181 1/20 0.59
CYP2A6 P11509 1/20 0.59
CYP2B6 P20813 1/20 0.59
KDM4E B2RXH2 7/20 0.48
ALDH1A1 P00352 4/20 0.48
TDP1 Q9NUW8 3/20 0.48
HPGD P15428 3/20 0.48
MEN1 O00255 2/20 0.48
MAPT P10636 2/20 0.48
KMT2A Q03164 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
CYP17A1 P05093 1/20 0.47
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
POLB P06746 1/20 0.47
TSHR P16473 1/20 0.45
NAPRT Q6XQN6 1/20 0.45
HSD17B10 Q99714 5/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL28113439 0.97 CYP3A4 (0.61) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Benzene SCHEMBL28135573 0.88 CYP3A4 (0.57) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Pyrazine SCHEMBL28096471 0.88 CYP3A4 (0.57) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Pyridine SCHEMBL30984530 0.84 CYP3A4 (0.70) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Benzene SCHEMBL29089513 0.84 L3MBTL1 (0.55) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Benzene SCHEMBL28420098 0.84 L3MBTL1 (0.55) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Benzene SCHEMBL28031566 0.81 KDM4E (0.52) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL3545 0.81 L3MBTL1 (0.57) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL16291133 0.81 L3MBTL1 (0.57) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL28591996 0.79 KDM4E (0.52) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103534252-B Benzomorpholine derivatives and its preparation method and application 上海艾力斯医药科技有限公司 2016-08-24 CN disclosed