Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | CES1 | P23141 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765 | 0.98 | MAPK1 (1.00) | MAPK1LMNAMEN1NPC1MAPT | |
| Bromide SCHEMBL8031021 | 0.96 | MAPK1 (0.96) | MAPK1LMNAMEN1NPC1MAPT | |
| Ammonia Solution, Strong SCHEMBL17180526 | 0.96 | MAPK1 (0.96) | MAPK1LMNAMEN1NPC1MAPT | |
| Acetic Acid SCHEMBL28719519 | 0.94 | MAPK1 (0.92) | MAPK1LMNAMEN1NPC1MAPT | |
| SCHEMBL6703081 | 0.92 | MAPK1 (0.88) | MAPK1LMNAMEN1NPC1MAPT | |
| 4-Nitrobenzoic Acid SCHEMBL27616739 | 0.90 | MAPK1 (0.85) | MAPK1LMNAMEN1NPC1MAPT | |
| Ethylene Glycol SCHEMBL10838204 | 0.90 | MAPK1 (0.85) | MAPK1LMNAMEN1NPC1MAPT | |
| SCHEMBL27691783 | 0.88 | MAPK1 (0.81) | MAPK1LMNAMEN1NPC1MAPT | |
| Acetohydroxamic Acid SCHEMBL28835753 | 0.88 | MAPK1 (0.81) | MAPK1LMNAMEN1NPC1MAPT | |
| SCHEMBL40825 | 0.87 | MAPK1 (0.79) | MAPK1LMNAMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105949117-B | Sorafenib derivative of the similar structures containing chalcone and its preparation method and application | 江西科技师范大学 | 2018-03-13 | — | — | CN | disclosed |
| CN-105949117-A | Sorafenib derivatives containing chalcone-like structures as well as preparation method and application of Sorafenib derivatives | 江西科技师范大学 | 2016-09-21 | — | — | CN | disclosed |