Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810289 | 0.80 | GRM2 (0.51) | GRM2RORC | |
| SCHEMBL171300 | 0.71 | GRM2 (0.81) | GRM2 | |
| SCHEMBL1339018 | 0.66 | GRM2 (0.51) | GRM2 | |
| SCHEMBL1339020 | 0.66 | GRM2 (0.51) | GRM2 | |
| SCHEMBL104969 | 0.65 | NPC1 (0.48) | RORC | |
| SCHEMBL1338801 | 0.63 | GRM2 (0.43) | GRM2 | |
| SCHEMBL178453 | 0.60 | MAPK1 (0.53) | RORC | |
| SCHEMBL657241 | 0.60 | LMNA (0.45) | RORC | |
| SCHEMBL16944207 | 0.60 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17675010 | 0.59 | PDE1C (0.49) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| EP-2205565-B1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2205565-B1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2009033703-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | GRM2, GRM1, GRIN2C | GRM2 1/4885RORC 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.