Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27811062 | 0.91 | SIRT2 (0.64) | SIRT2CDK4CCND1CDK2PDE4A | |
| SCHEMBL28101313 | 0.88 | SIRT2 (0.54) | SIRT2GSK3BCDK4CCND1CDK2 | |
| SCHEMBL28101312 | 0.88 | SIRT2 (0.54) | SIRT2GSK3BGSK3ACDK4CCND1 | |
| SCHEMBL28101198 | 0.88 | SIRT2 (0.56) | SIRT2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL8166825 | 0.85 | SIRT2 (0.68) | SIRT2CDK4CCND1CDK2CCNA2 | |
| SCHEMBL28101306 | 0.84 | SIRT2 (0.54) | SIRT2GSK3BCDK4CCND1CDK2 | |
| SCHEMBL28101203 | 0.82 | IDH1 (0.60) | SIRT2GSK3BGSK3ACDK4CCND1 | |
| SCHEMBL28101304 | 0.81 | SIRT2 (0.53) | SIRT2CDK4CCND1CDK2PDE4A | |
| SCHEMBL8167903 | 0.81 | CCNE2 (0.72) | SIRT2GSK3BCDK4CCND1CDK2 | |
| SCHEMBL28101299 | 0.80 | SIRT2 (0.51) | SIRT2CDK4CCND1CDK2CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |