Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | QPCT | Q16769 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28101306 | 0.94 | SIRT2 (0.54) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL27811062 | 0.90 | SIRT2 (0.64) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL28101239 | 0.88 | SIRT2 (0.55) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL28101319 | 0.88 | SIRT2 (0.55) | SIRT2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28101312 | 0.88 | SIRT2 (0.54) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL28101304 | 0.84 | SIRT2 (0.53) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL8166825 | 0.84 | SIRT2 (0.68) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL28101299 | 0.83 | SIRT2 (0.51) | SIRT2CAMK2DCCNE2CDK4CCND1 | |
| SCHEMBL28101202 | 0.82 | SIRT2 (0.55) | SIRT2GSK3BPDE4APDE4BPDE4C | |
| SCHEMBL20624143 | 0.81 | CDK4 (0.76) | SIRT2CAMK2DCCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |