Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28589094 | 0.79 | MCL1 (0.42) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL31177905 | 0.78 | EPHX1 (0.47) | HTTMAPTALOX15HBBEPHX1 | |
| SCHEMBL5688901 | 0.75 | EPHX1 (0.48) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL8913473 | 0.74 | EPHX1 (0.47) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL6527310 | 0.70 | MCL1 (0.49) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL3257539 | 0.70 | MCL1 (0.49) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL2409379 | 0.70 | CHRM3 (0.37) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL120709 | 0.67 | MEN1 (0.48) | MAPTPOLBGAAHSD17B10MEN1 | |
| SCHEMBL13446994 | 0.67 | ALDH1A1 (0.49) | HTTMAPTALOX15HBBMCL1 | |
| SCHEMBL6244095 | 0.67 | MCL1 (0.45) | HTTMAPTALOX15HBBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316856-B | A kind of synthetic method of phenacylidene malonate analog derivative | 浙江工业大学 | 2019-07-26 | — | — | CN | claimed |
| CN-106316856-A | Synthesis method of benzoyl methylene malonate derivatives | 浙江工业大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316856-B | A kind of synthetic method of phenacylidene malonate analog derivative | 浙江工业大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106316856-B | A kind of synthetic method of phenacylidene malonate analog derivative | 浙江工业大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106316856-B | A kind of synthetic method of phenacylidene malonate analog derivative | 浙江工业大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106349073-B | A kind of synthetic method of phenacylidene malonic acid ester type compound | 浙江工业大学 | 2019-02-01 | — | — | CN | disclosed |
| CN-106349073-A | Method for synthesizing benzoyl methylene malonic ester compound | 浙江工业大学 | 2017-01-25 | — | — | CN | disclosed |
| CN-106316856-A | Synthesis method of benzoyl methylene malonate derivatives | 浙江工业大学 | 2017-01-11 | — | — | CN | disclosed |