Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.56 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL29262501 | 1.00 | PRCP (0.56) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Octanol SCHEMBL1850228 | 0.86 | PRCP (0.57) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Dodecanoate SCHEMBL17223917 | 0.84 | PRCP (0.56) | PRCPTLR2ALDH1A1MEN1KMT2A | |
| Proline SCHEMBL28032319 | 0.84 | PRCP (0.56) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Dodecanoate SCHEMBL17223919 | 0.84 | PRCP (0.56) | PRCPTLR2ALDH1A1MEN1KMT2A | |
| Tetrahexylammonium SCHEMBL28000488 | 0.84 | PRCP (0.56) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Decanoic Acid SCHEMBL13279505 | 0.84 | PRCP (0.56) | PRCPTLR2ALDH1A1MEN1KMT2A | |
| Proline SCHEMBL27518126 | 0.84 | PRCP (0.56) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Palmitamide SCHEMBL2983852 | 0.83 | PRCP (0.55) | PRCPTLR2DPP7S1PR3ALDH1A1 | |
| Proline SCHEMBL30939428 | 0.83 | PRCP (0.55) | PRCPTLR2DPP7S1PR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106362549-B | It is a kind of to trap nitric oxide production method using amino acid anionic functional ionic liquid | 浙江大学 | 2019-10-08 | — | — | CN | claimed |
| CN-106362549-A | Method for capturing nitric oxide by using amino acid anion functional ionic liquid | 浙江大学 | 2017-02-01 | — | — | CN | claimed |
| CN-106008274-A | Preparation method of N,N'-dicyclohexylurea | 绍兴文理学院 | 2016-10-12 | — | — | CN | claimed |
| CN-106362549-B | It is a kind of to trap nitric oxide production method using amino acid anionic functional ionic liquid | 浙江大学 | 2019-10-08 | — | — | CN | disclosed |
| CN-106362549-A | Method for capturing nitric oxide by using amino acid anion functional ionic liquid | 浙江大学 | 2017-02-01 | — | — | CN | disclosed |
| CN-106008274-A | Preparation method of N,N'-dicyclohexylurea | 绍兴文理学院 | 2016-10-12 | — | — | CN | disclosed |