Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28101763 | 1.00 | ALOX15 (0.44) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12414724 | 0.81 | SCN4A (0.34) | ALOX15CYP1A2SMN1; SMN2CYP2D6TSHR | |
| SCHEMBL13003643 | 0.81 | TDP1 (0.42) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12414718 | 0.81 | SCN4A (0.34) | ALOX15CYP1A2SMN1; SMN2CYP2D6TSHR | |
| SCHEMBL189149 | 0.80 | — | — | |
| SCHEMBL16103647 | 0.80 | — | — | |
| SCHEMBL13030933 | 0.79 | SLC7A5 (0.42) | CYP1A2CYP2D6TSHRSCN4ACYP3A4 | |
| SCHEMBL13030932 | 0.79 | SLC7A5 (0.42) | CYP1A2CYP2D6TSHRSCN4ACYP3A4 | |
| SCHEMBL4200761 | 0.79 | SMN1; SMN2 (0.38) | CYP1A2SMN1; SMN2CYP2D6TSHRSCN4A | |
| SCHEMBL224726 | 0.78 | ALOX15 (0.46) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108434149-A | For the regulated treatments of HSPC of Rb positive abnormal cell proliferations | G1治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-108283644-A | To the instantaneous protection of normal cell during chemotherapy | G1治疗公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105407889-B | HSPC-sparing therapy for Rb-positive abnormal cell proliferation | G1治疗公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-105473140-B | Transient protection of normal cells during chemotherapy | G1治疗公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-106008533-B | CDK inhibitor | G1治疗公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-107417691-A | Efficient anti-superfluous raw agent and anti-proliferative agent | G1治疗公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106967074-A | CDK inhibitor | G1治疗公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-103936745-B | Cdk inhibitors | G1治疗公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-106008533-A | Cdk inhibitors | G1治疗公司 | 2016-10-12 | — | — | CN | disclosed |