Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.77 |
| ▸ | SYK | P43405 | 2/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28103922 | 0.91 | PDE4B (0.73) | PDE4BSYKZAP70MAPK9TYK2 | |
| SCHEMBL11166045 | 0.88 | PDE4B (0.62) | PDE4BMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL28103925 | 0.88 | PDE4B (0.66) | PDE4BSYK | |
| SCHEMBL27930309 | 0.88 | PDE4B (0.69) | PDE4BSYKZAP70MAPK8TYK2 | |
| SCHEMBL28103913 | 0.88 | PDE4B (0.69) | PDE4BSYKMAPK8MAPK9MEN1 | |
| SCHEMBL5265201 | 0.84 | PDE4B (0.60) | PDE4BMAPK8MEN1ALDH1A1LMNA | |
| SCHEMBL5264668 | 0.80 | PDE4B (0.56) | PDE4BSYKZAP70MAPK8TYK2 | |
| SCHEMBL11160276 | 0.79 | ALDH1A1 (0.67) | PDE4BSYKMEN1ALDH1A1LMNA | |
| SCHEMBL1313173 | 0.78 | MAPK8 (0.58) | PDE4BSYKZAP70MAPK8MAPK9 | |
| SCHEMBL3256027 | 0.78 | MEN1 (0.55) | PDE4BMAPK8MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214489-B | One class Mutiple Targets inhibitors of kinases with anti-tumor activity and preparation method thereof | 中国人民解放军第二军医大学 | 2016-10-26 | — | — | CN | disclosed |