Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 16/20 | 0.57 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2812648 | 0.81 | GRM2 (0.40) | GRM2 | |
| SCHEMBL1033931 | 0.73 | GRM2 (1.00) | GRM2 | |
| SCHEMBL1338801 | 0.69 | GRM2 (0.43) | GRM2BRD9 | |
| SCHEMBL2186301 | 0.69 | GRM2 (0.47) | GRM2 | |
| SCHEMBL1339310 | 0.68 | GRM2 (0.41) | GRM2BRD9 | |
| SCHEMBL2188130 | 0.67 | GRM2 (0.46) | GRM2 | |
| SCHEMBL1039006 | 0.66 | ALDH1A1 (0.55) | GRM2ALDH1A1LMNA | |
| SCHEMBL1339289 | 0.66 | GRM2 (0.40) | GRM2 | |
| SCHEMBL1339105 | 0.66 | GRM2 (0.40) | GRM2 | |
| SCHEMBL1339104 | 0.66 | GRM2 (0.40) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722894-B2 | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| EP-2205565-B1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2205565-B1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | JANSSEN PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2009033703-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1 H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240706-A1 | 1,3-DISUBSTITUTED-4-PHENYL-1H-PYRIDIN-2-ONES | GRM2, GRM1, GRIN2C | GRM2 1/4885BRD9 3482/4885ALDH1A1 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.