Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 12/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618488 | 0.81 | MKNK1 (0.53) | KDRPDGFRBEGFR | |
| SCHEMBL5004998 | 0.79 | RIPK2 (0.50) | RIPK2RIPK3EGFRLRRK2 | |
| SCHEMBL28105784 | 0.71 | MKNK1 (0.46) | RIPK2RIPK3EGFR | |
| SCHEMBL28106300 | 0.70 | IKBKB (0.46) | RIPK2RIPK3EGFR | |
| SCHEMBL5005669 | 0.70 | RIPK2 (0.41) | RIPK2RIPK3EGFR | |
| Hydrochloric Acid SCHEMBL5001541 | 0.69 | RIPK2 (0.40) | RIPK2RIPK3EGFR | |
| SCHEMBL5004740 | 0.69 | CCNT1 (0.37) | — | |
| SCHEMBL5002068 | 0.69 | RIPK2 (0.40) | RIPK2RIPK3EGFRLRRK2 | |
| SCHEMBL5001423 | 0.68 | RIPK2 (0.38) | RIPK2RIPK3EGFR | |
| SCHEMBL28106292 | 0.68 | LRRK2 (0.52) | KDRPDGFRBRIPK2RIPK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797582-B | Substituted pyrrolo-pyrimidine radicals amino-benzothiazole ketone as MKNK inhibitors of kinases | 拜耳药业股份公司 | 2016-10-12 | — | — | CN | claimed |