Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CD38 | P28907 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618361 | 0.83 | MKNK1 (0.49) | ALDH1A1PKM | |
| SCHEMBL16962719 | 0.77 | MKNK1 (0.58) | MEN1KMT2AEGFR | |
| SCHEMBL5004998 | 0.76 | RIPK2 (0.50) | RIPK3RIPK1EGFRRIPK2 | |
| SCHEMBL15618496 | 0.73 | ALDH1A1 (0.53) | ALDH1A1PKM | |
| SCHEMBL28105784 | 0.70 | MKNK1 (0.46) | IKBKBRIPK3RAB9AEGFRRIPK2 | |
| SCHEMBL28106293 | 0.70 | KDR (0.44) | RIPK3EGFRRIPK2 | |
| SCHEMBL2197137 | 0.69 | TGFBR1 (0.50) | IKBKBCHUKRIPK3RIPK1MEN1 | |
| SCHEMBL5010147 | 0.68 | CCNT1 (0.51) | — | |
| SCHEMBL5008165 | 0.68 | CCNT1 (0.43) | — | |
| SCHEMBL5005669 | 0.67 | RIPK2 (0.41) | RIPK3EGFRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797582-B | Substituted pyrrolo-pyrimidine radicals amino-benzothiazole ketone as MKNK inhibitors of kinases | 拜耳药业股份公司 | 2016-10-12 | — | — | CN | disclosed |