SCHEMBL28107248

SCHEMBL28107248

O=C(CBr)c1ccccc1.O=C(c1ccccc1)C(Br)C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 8/20 0.61
PTPN1 P18031 6/20 0.61
MDM2 Q00987 1/20 0.42
TDP1 Q9NUW8 3/20 0.41
CES1 P23141 2/20 0.41
MAPK1 P28482 2/20 0.41
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TSHR P16473 1/20 0.40
TRPA1 O75762 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HIF1A Q16665 1/20 0.39
PDPK1 O15530 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL396812 0.88 CES1 (0.48) GSK3BPTPN1MDM2TDP1CES1
SCHEMBL28106996 0.80 GSK3B (0.70) GSK3BPTPN1MDM2TDP1CES1
SCHEMBL19331717 0.78 GSK3B (1.00) GSK3BPTPN1TDP1CES1MAPK1
SCHEMBL7621 0.78 GSK3B (1.00) GSK3BPTPN1TDP1CES1MAPK1
SCHEMBL18849535 0.78 GSK3B (1.00) GSK3BPTPN1TDP1CES1MAPK1
Bromide SCHEMBL28774450 0.76 GSK3B (0.95) GSK3BPTPN1TDP1CES1MAPK1
Methane SCHEMBL7161301 0.76 GSK3B (0.95) GSK3BPTPN1TDP1CES1MAPK1
Fluoride SCHEMBL27997580 0.76 GSK3B (0.95) GSK3BPTPN1TDP1CES1MAPK1
Water SCHEMBL28144749 0.76 GSK3B (0.95) GSK3BPTPN1TDP1CES1MAPK1
Hydrogen Sulfide SCHEMBL7496567 0.76 GSK3B (0.95) GSK3BPTPN1TDP1CES1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103936819-B Hepatitis c virus inhibitors 百时美施贵宝公司 2016-11-16 CN disclosed