Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252133 | 0.78 | — | — | |
| SCHEMBL3257380 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL8080870 | 0.73 | — | — | |
| Piperazine SCHEMBL27482822 | 0.70 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Aziridine SCHEMBL6683829 | 0.69 | — | — | |
| Piperazine SCHEMBL28841590 | 0.67 | — | — | |
| SCHEMBL11600308 | 0.67 | — | — | |
| Piperazine SCHEMBL11268084 | 0.67 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL8441646 | 0.67 | — | — | |
| Piperazine SCHEMBL28004662 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103612-B | Fluoro-containing coating composition and article | ＡＧＣ株式会社 | 2018-11-30 | — | — | CN | disclosed |
| CN-106103612-A | Fluoro-containing coating compositions and article | 旭硝子株式会社 | 2016-11-09 | — | — | CN | disclosed |