Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569859 | 0.86 | KMT2A (0.36) | KMT2ACYP2A6TRIM24TRIM33CCNT1 | |
| SCHEMBL1352440 | 0.77 | MAPK1 (0.57) | KMT2ACYP2A6TRIM24TRIM33IMPDH2 | |
| SCHEMBL28006116 | 0.69 | KMT2A (0.40) | KMT2ACYP2A6IMPDH2CCNT1CDK9 | |
| SCHEMBL12253387 | 0.69 | KMT2A (0.40) | KMT2ATRIM24TRIM33CCNT1CDK9 | |
| SCHEMBL23830299 | 0.69 | KMT2A (0.40) | KMT2ACYP2A6IMPDH2CCNT1CDK9 | |
| SCHEMBL1696892 | 0.68 | KMT2A (0.55) | KMT2ACYP2A6TRIM24TRIM33IMPDH2 | |
| SCHEMBL5263827 | 0.68 | KMT2A (0.54) | KMT2ACYP2A6TRIM24TRIM33IMPDH2 | |
| SCHEMBL31748624 | 0.63 | CYP2A6 (0.41) | KMT2ACYP2A6TRIM24TRIM33IMPDH2 | |
| SCHEMBL23094481 | 0.63 | CDK8 (0.40) | KMT2ACYP2A6TRIM24TRIM33CCNT1 | |
| SCHEMBL16044258 | 0.62 | CYP2A6 (0.51) | KMT2ACYP2A6IMPDH2PIM3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061973-A | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2016-10-26 | — | — | CN | disclosed |