Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23830299 | 0.86 | KMT2A (0.40) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL29936350 | 0.79 | MAPK1 (0.57) | KMT2AMAPK1CCNT1CDK9HASPIN | |
| SCHEMBL12253387 | 0.79 | KMT2A (0.40) | KMT2AMAPK1CCNT1CDK9HASPIN | |
| SCHEMBL1352440 | 0.79 | MAPK1 (0.57) | KMT2AMAPK1CCNT1CDK9HASPIN | |
| SCHEMBL30259037 | 0.73 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL20846079 | 0.73 | ALDH1A1 (0.41) | MAPK1 | |
| SCHEMBL650607 | 0.73 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL1696892 | 0.72 | KMT2A (0.55) | KMT2AMAPK1CCNT1CDK9HASPIN | |
| SCHEMBL14655319 | 0.71 | JAK2 (0.40) | — | |
| SCHEMBL15569859 | 0.71 | KMT2A (0.36) | KMT2ACCNT1CDK9HASPINCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104507945-A | Pyrrolo[2,3-B]pyrazines as SYK inhibitors | HOFFMANN LA ROCHE | 2015-04-08 | — | — | CN | disclosed |