Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17686007 | 0.90 | STS (0.47) | STSKDM4EPKMNR1H2NR1H3 | |
| SCHEMBL25650104 | 0.85 | OPRD1 (0.52) | STSKDM4EPKMMETTL3LMNA | |
| SCHEMBL1682323 | 0.85 | OPRD1 (0.52) | STSKDM4EPKMMETTL3LMNA | |
| SCHEMBL7860304 | 0.85 | NR1H2 (0.52) | STSKDM4EPKMNR1H2NR1H3 | |
| SCHEMBL8923537 | 0.85 | NR1H2 (0.52) | STSKDM4EPKMNR1H2NR1H3 | |
| SCHEMBL7860307 | 0.85 | NR1H2 (0.52) | STSKDM4EPKMNR1H2NR1H3 | |
| SCHEMBL8007362 | 0.79 | JAK2 (0.41) | STSKDM4EPKMNR1H2NR1H3 | |
| SCHEMBL7985552 | 0.77 | KDM4E (0.69) | STSKDM4EPKMKEAP1NFE2L2 | |
| SCHEMBL924409 | 0.77 | KMT2A (0.45) | STSKDM4EPKMKEAP1NFE2L2 | |
| SCHEMBL1272940 | 0.76 | ATM (0.42) | STSKDM4EPKMKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103517910-B | Morpholine-spirocyclic piperidine amides as modulators of ion channels | 沃泰克斯药物股份有限公司 | 2016-12-14 | — | — | CN | disclosed |