Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22565386 | 0.91 | ACKR3 (0.61) | HSD11B1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24881303 | 0.87 | HSD11B1 (0.52) | HSD11B1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL22873378 | 0.87 | HSD11B1 (0.52) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL26366853 | 0.87 | HSD11B1 (0.52) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL26367076 | 0.87 | HSD11B1 (0.52) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL22565385 | 0.84 | HSD11B1 (0.49) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL22565347 | 0.81 | PRKAA2 (0.47) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL2591980 | 0.80 | HSD11B1 (1.00) | HSD11B1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL24267248 | 0.79 | PRKAA2 (0.47) | HSD11B1ALDH1A1CNR2ACKR3PRKAA2 | |
| SCHEMBL28836616 | 0.78 | SCD (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | claimed |
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | disclosed |