Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818841 | 0.90 | IRAK4 (0.54) | HTTMAPK1CA1CA2CA7 | |
| SCHEMBL27883374 | 0.85 | MAPT (0.57) | HTTCA12CA1CA2CA7 | |
| SCHEMBL6766286 | 0.84 | HTT (0.43) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL29603325 | 0.84 | MAPT (0.59) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL152563 | 0.84 | MAPT (0.59) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL10372693 | 0.83 | HTT (0.45) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL9504326 | 0.83 | CDC25B (0.50) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL4487895 | 0.83 | MAPK1 (0.46) | HTTMAPK1HPGDKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL4229730 | 0.82 | MAPT (0.58) | HTTMAPK1CA12CA1CA2 | |
| SCHEMBL28776139 | 0.82 | MAPT (0.58) | HTTMAPK1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103517910-B | Morpholine-spirocyclic piperidine amides as modulators of ion channels | 沃泰克斯药物股份有限公司 | 2016-12-14 | — | — | CN | disclosed |