Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxypurinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH known ✓ | P47989 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 8/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 8/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 8/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 8/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.34 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxypurinol SCHEMBL39154 | 0.78 | XDH (1.00) | XDHBLMHSD17B10KDM4E | |
| Oxypurinol SCHEMBL9003893 | 0.76 | XDH (0.96) | XDHBLMHSD17B10KDM4E | |
| Oxypurinol SCHEMBL9295181 | 0.75 | XDH (0.92) | XDHBLMHSD17B10KDM4E | |
| Cysteine SCHEMBL28009382 | 0.65 | PTGS1 (0.89) | PTGS1SLC7A11GRIA1GRIA2GRIA4 | |
| Cysteine SCHEMBL339562 | 0.65 | PTGS1 (1.00) | PTGS1SLC7A11GRIA1GRIA2GRIA4 | |
| Cysteine SCHEMBL95110 | 0.65 | — | — | |
| Cysteine SCHEMBL5705430 | 0.65 | PTGS1 (1.00) | PTGS1SLC7A11GRIA1GRIA2GRIA4 | |
| Cysteine SCHEMBL7898895 | 0.65 | PTGS1 (1.00) | PTGS1SLC7A11GRIA1GRIA2GRIA4 | |
| Cysteine SCHEMBL21110883 | 0.65 | PTGS1 (1.00) | PTGS1SLC7A11GRIA1GRIA2GRIA4 | |
| Cysteine SCHEMBL5705426 | 0.65 | PTGS1 (1.00) | PTGS1SLC7A11GRIA1GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103495173-B | Trauma care | 低温药理KF有限公司 | 2016-11-23 | — | — | CN | disclosed |