Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636706 | 0.90 | KMT2A (0.53) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL28763196 | 0.87 | KMT2A (0.54) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL6621712 | 0.86 | KMT2A (0.49) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL13098077 | 0.86 | KMT2A (0.53) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL23142270 | 0.86 | KMT2A (0.49) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL6625082 | 0.83 | KMT2A (0.57) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL4683311 | 0.83 | KMT2A (0.56) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL8634771 | 0.82 | KMT2A (0.51) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL27485588 | 0.82 | KMT2A (0.51) | KMT2AMEN1CYP1A2NPC1HPGD | |
| SCHEMBL13098618 | 0.82 | LTB4R (0.56) | KMT2ANPC1SMN1; SMN2MAPK10MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583201-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2016-12-14 | — | — | CN | disclosed |