Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM6A | O15550 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276307 | 0.91 | KDM4E (0.48) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL31132410 | 0.91 | KDM4E (0.48) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| Formic Acid Methyl Ester SCHEMBL19808817 | 0.87 | ERN1 (0.45) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL2012532 | 0.75 | KMT2A (0.49) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL29935851 | 0.75 | KMT2A (0.49) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| Hydrogen Sulfide SCHEMBL27687545 | 0.74 | KMT2A (0.47) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| Formic Acid SCHEMBL27894493 | 0.72 | ALDH1A1 (0.50) | ERN1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL276306 | 0.72 | MAPT (0.48) | ERN1KDM4EL3MBTL1NPC1HSP90AA1 | |
| Formic Acid SCHEMBL27791720 | 0.71 | ALDH1A1 (0.47) | ERN1KDM4ENPC1RAB9AHSP90AA1 | |
| Formic Acid SCHEMBL19808819 | 0.71 | CDC7 (0.47) | ERN1KDM4EL3MBTL1KMT2ACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146490-A | 5-hydroxyl-1,7-naphthyridine compounds, its preparation method and the pharmaceutical applications thereof replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2016-11-23 | — | — | CN | disclosed |