Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Etidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 2/20 | 0.50 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | FDPS | P14324 | 12/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etidronic Acid SCHEMBL9161286 | 0.90 | LMNA (0.65) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL18607 | 0.85 | LMNA (1.00) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL10532992 | 0.85 | LMNA (1.00) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL2320712 | 0.82 | LMNA (0.62) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL10941767 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL41737 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL7764099 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL5015174 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL10706794 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D | |
| Etidronic Acid SCHEMBL17961664 | 0.82 | LMNA (0.93) | LMNAFDPSPDE3AADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108289494-A | Polypeptides capable of producing glucan having α -1, 2 branches and uses thereof | 纳幕尔杜邦公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-107580606-A | Gelled dextran ethers | 纳幕尔杜邦公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-107404924-A | The dextran of oxidation | 纳幕尔杜邦公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107148472-A | The serine protease of Bacillus spec | 丹尼斯科美国公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-107109450-A | Enzymatically produced cellulose | 纳幕尔杜邦公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074985-A | The gelation dextran of enzymatic polymerization | 纳幕尔杜邦公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106232794-A | Comprise the Fabrid care composition of polyurethane, polyureas and/or polyurethaneurea polymer | 宝洁公司 | 2016-12-14 | — | — | CN | disclosed |