Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | PAM | P19021 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | UNG | P13051 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28893487 | 1.00 | ALDH1A1 (0.67) | ALDH1A1CYP2A6NR4A2PAMKEAP1 | |
| Benzaldehyde SCHEMBL2895864 | 0.89 | ALDH1A1 (0.58) | ALDH1A1CYP2A6NR4A2PAMKEAP1 | |
| Benzaldehyde SCHEMBL28055948 | 0.89 | ALDH1A1 (0.58) | ALDH1A1CYP2A6NR4A2PAMKEAP1 | |
| Benzaldehyde SCHEMBL28078416 | 0.87 | ALDH1A1 (0.56) | ALDH1A1CYP2A6NR4A2PAMKEAP1 | |
| Benzaldehyde SCHEMBL28122866 | 0.86 | ALDH1A1 (0.67) | ALDH1A1CYP2A6PAMKMT2AUNG | |
| Benzaldehyde SCHEMBL11228895 | 0.86 | ALDH1A1 (0.67) | ALDH1A1CYP2A6PAMKMT2AUNG | |
| Benzaldehyde SCHEMBL7190600 | 0.85 | ALDH1A1 (0.82) | ALDH1A1CYP2A6PAMKMT2AUNG | |
| Benzaldehyde SCHEMBL7762594 | 0.85 | ALDH1A1 (0.82) | ALDH1A1CYP2A6PAMKMT2AUNG | |
| Benzaldehyde SCHEMBL28945328 | 0.84 | ALDH1A1 (0.93) | ALDH1A1CYP2A6KMT2AUNGSMN1; SMN2 | |
| Benzaldehyde SCHEMBL28324856 | 0.84 | ALDH1A1 (0.93) | ALDH1A1CYP2A6KMT2AUNGSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111205631-A | Self-repairing polyurethane elastomer by electric heating and preparation method thereof | 青岛科技大学 | 2020-05-29 | — | — | CN | disclosed |
| CN-108148714-A | A kind of peacock courage wine and preparation method thereof | 重庆菲利克思农业发展有限公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-104388269-B | Crocodile penis liquor and preparation method thereof | 胡诚礼 | 2017-01-25 | — | — | CN | disclosed |