Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 3/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861922 | 0.81 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2 | |
| Nitrobenzene SCHEMBL10522007 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| SCHEMBL13701005 | 0.72 | SMN1; SMN2 (0.41) | ALDH1A1LMNAGABRPGABRDGABRA1 | |
| Nitrobenzene SCHEMBL10522235 | 0.72 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| Nitrobenzene SCHEMBL10522684 | 0.69 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| Nitrobenzene SCHEMBL10522327 | 0.69 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSMN1; SMN2KMT2A | |
| Nitrobenzene SCHEMBL10521301 | 0.67 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTRAB9ANPC1 | |
| Nitrobenzene SCHEMBL28322104 | 0.67 | ALDH1A1 (0.84) | ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL7618865 | 0.66 | SMN1; SMN2 (0.50) | ALDH1A1MAPTSMN1; SMN2POLB | |
| Hexamethylbenzene SCHEMBL28025771 | 0.65 | ALDH1A1 (0.80) | ALDH1A1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255689-B | Heteroaryl SYK Inhibitors | 勃林格殷格翰国际有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-110183440-A | Heteroaryl SYK inhibitor | 勃林格殷格翰国际有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-108026080-A | Pyrazolyl-substituted heteroaryl compounds and their use as medicaments | 勃林格殷格翰国际有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-106255689-A | Heteroaryl syk inhibitors | 勃林格殷格翰国际有限公司 | 2016-12-21 | — | — | CN | disclosed |