Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 7/20 | 0.46 |
| ▸ | ACACA | Q13085 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221705 | 0.85 | CKS1B (0.48) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL8214675 | 0.84 | CKS1B (0.49) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL28926895 | 0.84 | CKS1B (0.49) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL16896516 | 0.83 | CKS1B (0.51) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL28642833 | 0.83 | CKS1B (0.46) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL28120169 | 0.83 | CKS1B (0.46) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL16896437 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL8222029 | 0.80 | CKS1B (0.53) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL13419702 | 0.80 | ACACB (0.49) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL28648284 | 0.80 | CKS1B (0.45) | CKS1BSKP1SKP2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106456619-A | Bicyclic heterocyclic derivatives as IRAK4 inhibitors | 奥列基因发现技术有限公司 | 2017-02-22 | — | — | CN | disclosed |