Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 8/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.49 |
| ▸ | CDK9 | P50750 | 7/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | CCNH | P51946 | 3/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376249 | 0.92 | EGFR (0.61) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL29205109 | 0.89 | EGFR (0.58) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18377056 | 0.89 | EGFR (0.60) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18376844 | 0.88 | EGFR (0.65) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18376829 | 0.87 | EGFR (0.60) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL29368834 | 0.87 | EGFR (0.62) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18376840 | 0.87 | EGFR (0.62) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18376831 | 0.87 | EGFR (0.56) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18376835 | 0.86 | EGFR (0.58) | EGFRJAK2BRD4CDK2CCNT1 | |
| SCHEMBL18377053 | 0.86 | EGFR (0.59) | EGFRJAK2BRD4CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316965-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-106316965-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2017-01-11 | — | — | CN | disclosed |