Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.60 |
| ▸ | CYCS | P99999 | 3/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TERT | O14746 | 4/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28173578 | 0.97 | TOP1 (0.63) | TOP1CYCSSTAT3STAT1RIPK1 | |
| SCHEMBL28008849 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL3999312 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL27899186 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL29962487 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL30616040 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL28022267 | 0.87 | TOP1 (0.72) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL7258299 | 0.85 | TOP1 (0.70) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL29520899 | 0.85 | TOP1 (0.70) | TOP1CYCSSTAT3STAT1TERT | |
| SCHEMBL28644858 | 0.85 | TOP1 (0.70) | TOP1CYCSSTAT3STAT1TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103772399-B | Preparation method and use of basic amino acid modified amidotetraphenylporphyrin compound | 中国医学科学院生物医学工程研究所 | 2017-01-25 | — | — | CN | disclosed |