Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278381 | 0.98 | ALOX5 (0.61) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL30152040 | 0.98 | ALOX5 (0.61) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL1278213 | 0.95 | ALOX5 (0.58) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL29489064 | 0.95 | ALOX5 (0.58) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL27958802 | 0.92 | ALOX5 (0.55) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL29489091 | 0.91 | ALOX5 (0.57) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL17383078 | 0.91 | ALOX5 (0.57) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL25833469 | 0.90 | ALOX5 (0.56) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL14814297 | 0.87 | ALOX5 (0.59) | ALOX5PARP14PRKDCEGFRTDO2 | |
| SCHEMBL12996531 | 0.87 | ALOX5 (0.71) | ALOX5PARP14PRKDCGPR3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103456899-B | Organic material, light-emitting component, light-emitting device, electronic equipment and illuminator | 株式会社半导体能源研究所 | 2017-03-01 | — | — | CN | disclosed |