Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | RARB | P10826 | 3/20 | 0.36 |
| ▸ | RARG | P13631 | 3/20 | 0.36 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11449463 | 0.92 | PTGS1 (0.38) | PTGS1PTGS2RARBRARGRARA | |
| SCHEMBL11448908 | 0.86 | PTGS1 (0.34) | PTGS1PTGS2RARBRARGRARA | |
| SCHEMBL321566 | 0.84 | NOTUM (0.42) | PTGS1PTGS2RARBRARGRARA | |
| SCHEMBL987764 | 0.72 | PTGS1 (0.43) | PTGS1PTGS2RARBRARGRARA | |
| SCHEMBL5656855 | 0.71 | RARB (0.45) | PTGS1PTGS2RARBRARGRARA | |
| SCHEMBL21658660 | 0.70 | PTGS1 (0.43) | PTGS1PTGS2POLB | |
| SCHEMBL19852058 | 0.70 | AKR1B1 (0.37) | — | |
| SCHEMBL15108061 | 0.68 | CNR2 (0.34) | PTGS1PTGS2POLB | |
| SCHEMBL20480546 | 0.68 | AKR1B1 (0.38) | PTGS1PTGS2CHRNA7POLB | |
| SCHEMBL16503890 | 0.67 | ABCG2 (0.33) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103269594-B | Synergistic herbicidal composition containing penoxsulam and benfuresate | 陶氏益农公司 | 2017-03-01 | — | — | CN | disclosed |